No Leftie Mice
I switched to a left-handed mouse for the first time, at the ripe age of 38. It's unviable, so I've stopped.
Finding a mouse was easy - my mouse is already symmetrical. Reversing the keys was just one command.
But you can't use a computer with that mouse. All the GUI shortcuts - Ctrl + c, Ctrl + f - all focus on the left-hand side of the keyboard. Every day demanded new adjustments, and eventually, I gave up.
It's a shame, as it felt strangely comfortable (but still strange, after using a right-handed mouse for a lifetime).